Comparison of Different Concentrations of Epinephrine on Hemodynamic Changes and Bleeding after Rhinoplasty in Patients under General Anesthesia


1 Assistant professor of Anesthesiology, Clinical Research Development Unit, Shafa Hospital, Kerman University of Medical Sciences, Kerman, Iran.

2 Otorhinolaryngologist, Clinical Research Development Unit ,Shafa Hospital,Kerman University of medical Science, Kerman ,Iran.

3 Anesthesiologist, Assistant Professor of Intensive Care, North Khorasan University of Medical Sciences, Bojnord, Iran

4 General physician, Kerman University of medical science, Kerman, Iran

5 Clinical Research Unit,Afzalipour Hospital,Kerman, Iran

6 Department of Anesthesiology, Shafa Hospital,Kerman university of medical sciences,Kerman ,Iran.



Background The present study was conducted to compare the effects of two different concentrations of epinephrine on hemodynamic changes and bleeding volume in patients undergoing rhinoplasty under general anesthesia.
Materials and Methods: This double-blind randomized clinical trial was conducted on 60 patients undergoing rhinoplasty in affiliated with Kerman University of Medical Sciences in Kerman, Iran, in 2019. The patients were equally divided into two groups administered with lidocaine/epinephrine injection at either dose of 1:100,000 (Group A) or 1:200,000 (Group B). Heart rate, systolic blood pressure (SBP), diastolic blood pressure (DBP), and mean arterial pressure (MAP) were compared between the two groups. In addition, bleeding and hemodynamic changes were recorded at different time points.
Results: About 90% of the patients were female, and gender distribution was comparable between the two groups (P=0.72). According to the results, the two groups were comparable in terms of demographic variables and the duration of the operation. Group A was found to have a lower level of bleeding (83.16 mL) compared to group B (108.07 mL); however, this difference was not statistically significant (P>0.05). In addition, there was no significant difference between the two groups in heart rate, SBP, DBP, and MAP at different time points (P>0.05).
Conclusion: The results of this study were indicative of the similar effect of the different doses of lidocaine: epinephrine (1:100,000 and 1:200,000) on the level of bleeding, SBP, DBP, and heart rate during rhinoplasty. Moreover, there was no difference between the results of the qualitative and quantitative assessment of bleeding in patients receiving epinephrine at different dosages.